BORGESlibraries: from phasing to structural bioinformatics

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Structural Bioinformatics: From the Sequence to Structure and Function

Proteins are the molecules of life which are involved in cellular processes. The functional specificity of a protein is linked to its structure. A great section of bioinformatics deals with the prediction, analysis and visualization of protein 3D structures. High-throughput methods for the determination of protein structures provide the information needed to build structure-activity relationshi...

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Motivation: Protein-protein complexes are known to play key roles in many cellular processes. However, they are often not accessible to experimental study because of their low stability and difficulty to produce the proteins and assemble them in native conformation. Thus, docking algorithms have been developed to provide an in silico approach of the problem. A protein-protein docking procedure ...

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Preface to Introduction to Structural Bioinformatics

While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics. This book aims to give an introduction into Structural Bioinformatics, which is where the previous topics meet to explore three dimensional protein structures through comput...

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ژورنال

عنوان ژورنال: Acta Crystallographica Section A Foundations and Advances

سال: 2015

ISSN: 2053-2733

DOI: 10.1107/s2053273315095856